DNA

A brief history of COMBINE

Standards for data exchange are critical to the development of any field. They enable researchers and practitioners to transport information reliably, to apply a variety of tools to their problems, and to reproduce scientific results. Over the past …

SBOL Visual: A Graphical Language for Genetic Designs

Synthetic Biology Open Language (SBOL) Visual is a graphical standard for genetic engineering. It consists of symbols representing DNA subsequences, including regulatory elements and DNA assembly features. These symbols can be used to draw …

Computational Synthetic Biology: Progress and the Road Ahead

Synthetic biology promises to leverage engineering principles to enable model-based design of genetic circuits. To be successful, advancements are needed in both experimental and computational methods to support this new approach. This paper focuses …

Design and Test of Genetic Circuits Using tt iBioSim

The simulation of biological systems prior to their physical implementation can save time, money, and potentially provide insights into alternate designs. This paper presents a simulation environment which allows for a visual design process …

Genetic design automation

Electronic design automation (EDA) tools have facilitated the design of ever more complex integrated circuits each year. Synthetic biology would also benefit from the development of genetic design automation (GDA) tools. Existing GDA tools require …